Masoud Pezeshkian says that if Iranians are facing economic hardship, “one of the main reasons” is the “longstanding enmity and inhumane sanctions imposed by the United States government and its allies,” and declares that “any aggression against the Supreme Leader of our country is tantamount to all‑out war against the Iranian nation.” He delivered this warning after Trump told Politico “It’s time to look for new leadership in Iran” and then repeated the line on Truth Social, describing Khamenei as a “sick man” and Iran as “the worst place to live,” remarks widely viewed in Tehran as explicit regime‑change signaling.